//steroid Hormones and Regulation of Ovarian Function
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چکیده
A family of C29 4,4-dimethylsterol intermediates in the cholesterol biosynthetic pathway from lanosterol has been found to induce oocytes to resume meiosis.[248] One of these sterols, 4,4-dimethyl-5α-cholest-8,14,24-triene-3β-ol, was extracted from human follicular fluid and named follicular fluid meiosis–activating substance (FF-MAS). A related compound, 4,4-dimethyl-5α-cholest-8,24-diene-3β-ol, was isolated from bull testis and called T-MAS. These compounds are synthesized from lanosterol by P450 14α-demethylase, which is encoded by the CYP51 gene. FF-MAS and T-MAS are present in micromolar concentrations in preovulatory follicle follicular fluid: 1.6 μM for FF-MAS and about half that for T-MAS.
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